Different postnatal ontogenic profiles of neurons containing beta (beta 1, beta 2 and beta 3) subunit mRNAs of GABAA receptor in the rat thalamus

Brain Res Dev Brain Res. 1991 Feb 22;58(2):289-92. doi: 10.1016/0165-3806(91)90017-d.

Abstract

The postnatal ontogeny of neurons containing different GABAA receptor beta (beta 1, beta 2 and beta 3) subunit mRNAs were examined in the rat thalamus using in situ hybridization histochemistry. Neurons containing beta 1 or beta 2 subunit mRNA developed remarkably postnatally, while most neurons were already strongly labeled with beta 3 probe at birth. However, beta 3 subunit mRNA decreased rapidly after birth, few cells being labeled with this probe at day 35 and thereafter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Animals, Newborn / growth & development
  • Animals, Newborn / metabolism
  • Male
  • Neurons / metabolism*
  • RNA, Messenger / classification
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A / genetics*
  • Thalamus / metabolism*

Substances

  • RNA, Messenger
  • Receptors, GABA-A