p53 regulation orchestrates the TGF-beta response

Cell. 2008 May 30;133(5):767-9. doi: 10.1016/j.cell.2008.05.013.

Abstract

Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation*
  • Ectoderm / cytology
  • Ectoderm / metabolism
  • Mesoderm / cytology
  • Mesoderm / metabolism
  • Transforming Growth Factor beta / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*
  • Xenopus / embryology*
  • Xenopus / metabolism

Substances

  • Transforming Growth Factor beta
  • Tumor Suppressor Protein p53