Abstract
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetogenins / chemistry
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Acetogenins / isolation & purification
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Acetogenins / pharmacology*
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Animals
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Annona / chemistry*
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Anthelmintics / chemistry
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Anthelmintics / isolation & purification
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Anthelmintics / pharmacology*
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Haemonchus / drug effects*
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Ovum / drug effects*
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Parasitic Sensitivity Tests
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Seeds / chemistry
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Spectrum Analysis
Substances
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Acetogenins
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Anthelmintics
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Plant Extracts