Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition

Sheng Zhang; Qin Wang

doi:10.1016/j.bbrc.2008.05.081

Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition

Biochem Biophys Res Commun. 2008 Aug 8;372(4):509-12. doi: 10.1016/j.bbrc.2008.05.081. Epub 2008 May 27.

Authors

Sheng Zhang¹, Qin Wang

Affiliation

¹ Medical Oncology, First People's Hospital, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China. wozhangsheng@hotmail.com

PMID: 18503756
DOI: 10.1016/j.bbrc.2008.05.081

Abstract

IL-12 is an important type 1 immune activation cytokine. It is known that macrophages and dendritic cells the major cell types producing this cytokine and that these cells may release both the biologically inactive form (IL-12p40) and active form (IL-12p70) of IL-12. In this review, the latest information regarding the regulatory mechanisms governing the production of IL-12p70 by these cells is evaluated.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases / immunology*
Dendritic Cells / immunology
Genetic Variation
Humans
Interleukin-12 / antagonists & inhibitors*
Interleukin-12 / genetics
Interleukin-12 / metabolism*
Macrophages / immunology
Mice

Substances

Interleukin-12