Abstract
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
MeSH terms
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Drug Evaluation, Preclinical
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Interleukin-1 Receptor-Associated Kinases / antagonists & inhibitors*
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Molecular Structure
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Pyridines / chemical synthesis
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Pyridines / chemistry
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Pyridines / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Protein Kinase Inhibitors
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Pyridines
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Interleukin-1 Receptor-Associated Kinases
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imidazo(1,2-a)pyridine