Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase

Bioorg Med Chem. 2008 Jun 1;16(11):6167-71. doi: 10.1016/j.bmc.2008.04.044. Epub 2008 Apr 25.

Abstract

Three new Lycopodium alkaloids, lycoparins A-C (1-3), have been isolated from the club moss Lycopodium casuarinoides. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Lycoparins C (3) exhibited an inhibitory activity against acetylcholinesterase, while lycoparins A (1) and B (2) did not show activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / blood
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Animals
  • Cattle
  • Cholinesterase Inhibitors / isolation & purification*
  • Cholinesterase Inhibitors / pharmacology*
  • Crystallography, X-Ray
  • Erythrocytes / enzymology
  • Hydrolysis / drug effects
  • Lycopodium / chemistry*
  • Quinolones / isolation & purification*
  • Quinolones / pharmacology*

Substances

  • Alkaloids
  • Cholinesterase Inhibitors
  • Quinolones
  • lycoparin A
  • lycoparin B
  • lycoparin C
  • Acetylcholinesterase