[Duration of second remission of Hodgkin's disease in children. Results of treatment achieved by the Polish Leukemia and Malignant Lymphoma Therapy in Children Group]

Pol Tyg Lek. 1991 Dec;46(48-49):924-8.
[Article in Polish]

Abstract

Recurrence was noted in 18.5% of 194 children, in which chemotherapy with MVPP regimen produced complete I remission. In 6 out of 36 children with recurrent disease MVPP regimen was repeated, while the remaining children were treated with B-DOPA alone or combined with MOPP regimen. Local radiotherapy was used in 17 children. The second complete remission was achieved in 30 (83.7%) children. Thirteen out of 36 patients died because of the progress of the disease (11 children), and for complications (2 children). Percentage of persisting 5- and 10-year II remissions are 58.2% and 54.6%, respectively. A 5- and 10-year survival rates in children with recurrent disease are 80.5% and 60.5%, respectively. Our relatively favourable results we associate--first of all--with the chemotherapy intensity.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Child
  • Combined Modality Therapy
  • Dihydroxyphenylalanine / administration & dosage
  • Female
  • Hodgkin Disease / mortality
  • Hodgkin Disease / therapy*
  • Humans
  • Male
  • Mechlorethamine / administration & dosage
  • Prednisolone / administration & dosage
  • Prednisone / administration & dosage
  • Procarbazine / administration & dosage
  • Remission Induction
  • Survival Rate
  • Vinblastine / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Vinblastine
  • Dihydroxyphenylalanine
  • Prednisolone
  • Prednisone

Supplementary concepts

  • MOPP protocol
  • MVPP protocol