In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium

Vaccine. 2008 Sep 19;26(40):5123-7. doi: 10.1016/j.vaccine.2008.03.061. Epub 2008 Apr 14.

Abstract

Cellular immunity is indispensable for efficient protection against intracellular bacterial infection. CD4+ and CD8+ T cells specific for a variety of antigenic peptides derived from particular bacteria are induced after the infection. T cells recognizing different antigenic peptides have been speculated to have different functions in terms of the protective immunity. We here induced individual CD4+ T cells specific for each antigenic peptide derived from Listeria monocytogenes independently with DNA vaccines using gene gun bombardment and compared the CD4+ T-cell populations for their ability on the specific protective immunity against lethal listerial challenge and analyzed their characteristics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biolistics
  • CD4-Positive T-Lymphocytes / immunology
  • Epitopes, T-Lymphocyte / chemistry
  • Epitopes, T-Lymphocyte / genetics
  • Epitopes, T-Lymphocyte / immunology*
  • Listeria monocytogenes / genetics
  • Listeria monocytogenes / immunology*
  • Listeriosis / immunology
  • Listeriosis / microbiology
  • Listeriosis / prevention & control
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Plasmids / genetics
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • Vaccines, DNA* / administration & dosage
  • Vaccines, DNA* / genetics
  • Vaccines, DNA* / immunology

Substances

  • Epitopes, T-Lymphocyte
  • Vaccines, DNA