Acral and palmo-plantar hyperpigmentation in a patient with disseminated hepatocellular carcinoma

Indian J Gastroenterol. 2007 Nov-Dec;26(6):292-3.

Abstract

Capecitabine (5-fluorouracil prodrug) is being evaluated for the management of hepatocellular carcinoma, and is associated with a peculiar skin reaction called hand and foot syndrome (HFS). We describe one patient with HCC and drug-induced HFS.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Capecitabine
  • Carcinoma, Hepatocellular / drug therapy*
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / adverse effects
  • Deoxycytidine / analogs & derivatives*
  • Diagnosis, Differential
  • Fluorouracil / administration & dosage
  • Fluorouracil / adverse effects
  • Fluorouracil / analogs & derivatives*
  • Foot Dermatoses / chemically induced*
  • Foot Dermatoses / diagnosis
  • Hand Dermatoses / chemically induced*
  • Hand Dermatoses / diagnosis
  • Humans
  • Liver Neoplasms / drug therapy*
  • Male
  • Middle Aged

Substances

  • Antimetabolites, Antineoplastic
  • Deoxycytidine
  • Capecitabine
  • Fluorouracil