Catatonia in autism: implications across the life span

Eur Child Adolesc Psychiatry. 2008 Sep;17(6):327-35. doi: 10.1007/s00787-008-0676-x. Epub 2008 Apr 21.

Abstract

Background: There is increasing evidence that catatonia is an important source of impairment in adolescents and adults with autism.

Aim: Review of the evaluation, diagnosis, differential diagnosis, and treatment of catatonia in autism.

Method: Presentation and discussion of a case-vignette spanning early childhood to adulthood.

Results: Autistic and catatonic symptoms overlap, yet catatonia is diagnosable in about one of seven adolescents and young adults with autism. Case-reports suggest that benzodiazepines and electroconvulsive therapy are effective treatments in the acute and maintenance phase for people with autism who develop catatonia.

Conclusions: Catatonia should be assessed in people with autism when there is an obvious and marked deterioration in movement, vocalizations, pattern of activities, self-care, and practical skills. Benzodiazepines and electroconvulsive therapy are favored options for acute and maintenance treatment in these cases. Further studies on the possible biological-genetic overlap between autism and catatonia would be helpful.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Autistic Disorder / diagnosis
  • Autistic Disorder / epidemiology*
  • Autistic Disorder / therapy
  • Benzodiazepines / therapeutic use
  • Catatonia / diagnosis
  • Catatonia / epidemiology*
  • Catatonia / therapy
  • Child
  • Comorbidity
  • Diagnosis, Differential
  • Electroconvulsive Therapy
  • Humans
  • Lorazepam / therapeutic use
  • Prevalence
  • Treatment Outcome

Substances

  • Benzodiazepines
  • Lorazepam