Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity

Nucleic Acids Symp Ser. 1991:(25):5-6.

Abstract

The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / chemistry
  • Adenine / pharmacology
  • Adenosine / analogs & derivatives*
  • Adenosine / chemistry
  • Adenosine / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Dideoxynucleosides / chemistry*
  • Dideoxynucleosides / pharmacology
  • HIV / drug effects*
  • Molecular Structure
  • Prospective Studies

Substances

  • Antiviral Agents
  • Dideoxynucleosides
  • carbovir
  • oxetanocin
  • Adenine
  • Adenosine
  • psicofuranine