Oleanane-type triterpenes from the flowers and roots of Saussurea muliensis

J Nat Prod. 2008 May;71(5):789-92. doi: 10.1021/np070618n. Epub 2008 Apr 18.

Abstract

Six new oleanane-type triterpenes (1- 6), along with five known compounds, were isolated from the flowers and roots of Saussurea muliensis. On the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques, the structures of the new compounds were characterized as 3beta,22alpha-dihydroxyolean-12-en-30-oic acid (1), 3alpha-(E)-caffeoyloxyolean-12-en-30-oic acid (2), 3alpha-(E)-coumaroyloxyolean-12-en-30-oic acid (3), 3alpha,22alpha-diacetoxy-20beta,21alpha,29-trihydroxy-30-norolean-12-ene (4), 3alpha,22alpha-diacetoxy-21alpha,29-dihydroxy-20beta-methoxy-30-norolean-12-ene (5), and 3alpha,22alpha-diacetoxy-20beta,21alpha-dihydroxy-29-palmityloxy-30-norolean-12-ene (6). The isolated compounds (1- 6) were not active against Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Candida albicans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus cereus / drug effects
  • Candida albicans / drug effects
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Escherichia coli / drug effects
  • Flowers / chemistry
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / isolation & purification*
  • Oleanolic Acid / pharmacology
  • Plant Roots / chemistry
  • Saussurea / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • Drugs, Chinese Herbal
  • Oleanolic Acid