Effects of amiodarone on the pharmacokinetics and toxicity of digoxin in laboratory animals

Acta Physiol Pharmacol Bulg. 1991;17(4):37-42.

Abstract

Some pharmacokinetic interactions between digoxin and amiodarone were studied in experiments on rabbits. An increase of digoxin serum levels was established in amiodarone-treated rabbits (amiodarone 30 mg/kg s. c. for five days administered alone or together with digoxin). The calculated elimination half-life(t1/2) and the area under the curve (AUC) of digoxin were increased and the digoxin clearance was decreased, being most pronounced in animals receiving a combination of amiodarone and digoxin for five days. Changes were observed neither in the digoxin toxicity in amiodarone-treated guinea-pigs nor in the serum levels of T4, T3 and TTH. The possible mechanisms of the digoxin-amiodarone interactions are discussed.

MeSH terms

  • Amiodarone / pharmacology*
  • Animals
  • Chinchilla
  • Creatinine / blood
  • Digoxin / pharmacokinetics*
  • Digoxin / toxicity*
  • Half-Life
  • Iodine Radioisotopes
  • Male
  • Rabbits
  • Radioimmunoassay
  • Thyrotropin / blood
  • Thyroxine / blood
  • Triiodothyronine / blood

Substances

  • Iodine Radioisotopes
  • Triiodothyronine
  • Digoxin
  • Thyrotropin
  • Creatinine
  • Amiodarone
  • Thyroxine