Mutations in sarcomeric protein genes not only lead to cardiomyopathy but also to congenital cardiovascular malformations

Clin Genet. 2008 Jul;74(1):16-9. doi: 10.1111/j.1399-0004.2008.00985.x. Epub 2008 Apr 8.

Abstract

Noncompaction of the ventricular myocardium is associated with de novo mutation in the beta-myosin heavy chain gene Budde et al. (2007) PLoS ONE 2: e1362 Homozygosity for a novel splice site mutation in the cardiac myosin-binding protein C gene causes severe neonatal hypertrophic cardiomyopathy Xin et al. (2007) Am J Med Genet 143: 2662-2667 Alpha-cardiac actin mutations produce atrial septal defects Matsson et al. (2008) Hum Mol Genet 17: 256-265.

MeSH terms

  • Cardiomyopathies / genetics*
  • Heart Defects, Congenital / genetics*
  • Humans
  • Muscle Proteins / genetics*
  • Mutation

Substances

  • Muscle Proteins