Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Chem Commun (Camb). 2008 Apr 21:(15):1765-7. doi: 10.1039/b718264c. Epub 2008 Feb 11.

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 A crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cathepsin L
  • Cathepsins / chemistry*
  • Cysteine Endopeptidases / chemistry*
  • Models, Molecular
  • Protein Conformation
  • Recombinant Fusion Proteins / chemistry*

Substances

  • Recombinant Fusion Proteins
  • silicatein alpha
  • Cathepsins
  • Cysteine Endopeptidases
  • Cathepsin L

Associated data

  • PDB/2VHS