Abstract
While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / therapeutic use
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Disease Models, Animal
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Liver / metabolism
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Liver / parasitology
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Liver / pathology
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Liver Diseases / drug therapy
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Liver Diseases / parasitology*
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Liver Diseases / pathology
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Malaria / drug therapy
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Malaria / mortality*
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Malaria / parasitology
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Malaria / pathology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred DBA
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Plasmodium chabaudi*
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Time Factors
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Antibodies
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Tumor Necrosis Factor-alpha