Abstract
Two alkaloids, 9beta,2'-dihydroxy-4'',5''-dimethoxy-lythran-12-one or 9beta-hydroxyvertine (1) and (2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate (2), as well as seven known alkaloids, lythrine (3), dehydrodecodine (4), lythridine (5), vertine (6), heimidine (7), lyfoline (8) and epi-lyfoline (9), were isolated from Heimia salicifolia. The structures of these compounds were elucidated by extensive spectroscopic techniques. Furthermore, the structures of 2, 3, and 6 were confirmed by X-ray crystallography, including absolute configuration determination of 2 and 6. Compounds 6 and 9 showed moderate antimalarial activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Anti-Infective Agents / pharmacology
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Antimalarials / pharmacology
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Cell Proliferation / drug effects
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Chlorocebus aethiops
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Crystallography, X-Ray
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Lythraceae / chemistry*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Structure
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects
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Quinazolines / chemistry*
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Quinazolines / isolation & purification
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Quinazolines / pharmacology
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Quinolines / chemistry*
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Quinolines / isolation & purification
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Quinolines / pharmacology
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Vero Cells
Substances
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(2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate
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9beta,2'-dihydroxy-4'',5''-dimethoxy-lythran-12-one
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Alkaloids
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Anti-Infective Agents
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Antimalarials
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Quinazolines
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Quinolines