Stem cell regulation and host defense: the logic and the paradox

Cell Stem Cell. 2008 Jan 10;2(1):1-2. doi: 10.1016/j.stem.2007.12.002.

Abstract

As a response against serious infection, there is often a need to produce more leukocytes to defend the organism against the infectious agent. In this issue of Cell Stem Cell, Goodell and colleagues (Feng et al., 2008) find a link between regulators of host defense and hematopoietic stem cells.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Bacterial Infections / immunology
  • Bone Marrow Transplantation / immunology
  • Bone Marrow Transplantation / methods
  • GTP-Binding Proteins / immunology
  • Hematopoietic Stem Cells / immunology*
  • Immunity*
  • Mice

Substances

  • Ifi1 protein, mouse
  • GTP-Binding Proteins