Abstract
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Protozoan / pharmacology*
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Cell Adhesion
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Cell Line
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Female
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HIV Infections / microbiology*
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HIV Infections / transmission
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HIV-1 / physiology*
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Humans
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Infectious Disease Transmission, Vertical
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Malaria, Falciparum / immunology*
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Placenta / immunology
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Placenta / parasitology
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Placenta / virology
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Placenta Diseases / immunology
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Placenta Diseases / parasitology
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Placenta Diseases / virology
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Plasmodium falciparum / immunology*
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Pregnancy
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Pregnancy Complications, Parasitic / immunology*
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Trophoblasts / parasitology
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Trophoblasts / virology
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Virus Replication / drug effects