Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton

Elisabeth Rodríguez-Güell; Gemma Agustí; Mercè Corominas; Pere-Joan Cardona; Marina Luquin; Esther Julián

doi:10.1128/CVI.00477-07

Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton

Clin Vaccine Immunol. 2008 May;15(5):893-6. doi: 10.1128/CVI.00477-07. Epub 2008 Mar 12.

Authors

Elisabeth Rodríguez-Güell¹, Gemma Agustí, Mercè Corominas, Pere-Joan Cardona, Marina Luquin, Esther Julián

Affiliation

¹ Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain.

Abstract

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adoptive Transfer*
Animals
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / immunology
Cell Wall Skeleton / administration & dosage*
Cell Wall Skeleton / immunology
Interferon-gamma / biosynthesis*
Mice
Mycobacterium / chemistry*
Mycobacterium / immunology
Tuberculosis, Pulmonary / immunology*
Tuberculosis, Pulmonary / therapy

Substances

Bacterial Vaccines
Cell Wall Skeleton
Interferon-gamma