Abstract
A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature o-QM generation in situ allows for the kinetic, diastereoselective construction of these motifs, providing entry to a number of unusual chroman spiroketal natural products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Products / chemical synthesis*
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Chromans / chemical synthesis*
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Ethers / chemistry*
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Furans / chemical synthesis*
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Indolequinones / chemistry*
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Molecular Structure
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Spiro Compounds / chemical synthesis*
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Stereoisomerism
Substances
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Biological Products
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Chromans
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Ethers
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Furans
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Indolequinones
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Spiro Compounds
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spiroketal
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quinone methide