Increased expression of Fc epsilon R2/CD23 on peripheral blood B lymphocytes and serum IgE levels in Kawasaki disease

Int Arch Allergy Appl Immunol. 1991;95(1):7-12. doi: 10.1159/000235446.

Abstract

We analyzed the expression of Fc epsilon R2/CD23 on the peripheral blood B lymphocytes of 10 patients with Kawasaki disease (KD) using a fluorescence-activated cell sorter. The absolute count of CD23-positive B lymphocytes and the ratio of CD23-positive B lymphocytes to B lymphocytes were high during the acute stage of KD in comparison to those during the convalescent stage and in control subjects. In addition, both the increased number of CD23-positive B lymphocytes and the increased serum IgE levels appeared during the latter part of the acute stage. These results suggest that the increased number of CD23-positive B lymphocytes during the latter part of the acute stage in KD reflect the activation of B lymphocytes and have an important role in IgE-mediated immunity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, CD / analysis*
  • Antigens, Differentiation, B-Lymphocyte / analysis*
  • B-Lymphocytes / immunology*
  • Cell Separation
  • Child
  • Child, Preschool
  • Convalescence
  • Female
  • Flow Cytometry
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin E / analysis*
  • Infant
  • Leukocyte Count
  • Lymphocyte Activation / immunology
  • Male
  • Mucocutaneous Lymph Node Syndrome / blood
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • Receptors, Fc / analysis*
  • Receptors, IgE

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E