Abstract
A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinin / antagonists & inhibitors
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Actinin / metabolism
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Adenosine Kinase / antagonists & inhibitors
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Adenosine Kinase / metabolism
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Aniline Compounds / chemical synthesis
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Aniline Compounds / chemistry
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Aniline Compounds / pharmacology*
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Animals
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CHO Cells
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Cell Line, Tumor
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Cell Movement / drug effects*
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Cricetinae
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Cricetulus
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Humans
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Integrin alpha4 / drug effects
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Integrin alpha4 / metabolism*
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Jurkat Cells
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RNA Interference
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Signal Transduction
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Small Molecule Libraries
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Tubercidin / analogs & derivatives*
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Tubercidin / chemical synthesis
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Tubercidin / chemistry
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Tubercidin / pharmacology
Substances
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Aniline Compounds
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JK 273
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PARVG protein, human
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Small Molecule Libraries
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Actinin
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Integrin alpha4
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Adenosine Kinase
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Tubercidin