Abstract
Three pyridinium inner salt alkaloids, lonijaposides A-C (1-3), based on an unprecedented skeleton of an N-substituted nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid, together with seven known iridoids, have been isolated from the flower buds of Lonicera japonica. Their structures were elucidated by spectroscopic and chemical analyses. Lonijaposide C (3) showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Flowers / chemistry
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Glucuronidase / drug effects
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Glucuronidase / metabolism
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology
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Lonicera / chemistry*
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Molecular Structure
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Neutrophils / drug effects
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Neutrophils / enzymology
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Plants, Medicinal / chemistry*
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Platelet Activating Factor / pharmacology
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Pyridinium Compounds / chemistry
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Pyridinium Compounds / isolation & purification*
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Pyridinium Compounds / pharmacology
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Rats
Substances
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Iridoids
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Platelet Activating Factor
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Pyridinium Compounds
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lonijaposide A
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lonijaposide B
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lonijaposide C
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Glucuronidase