Objective: To explore the effects of alcohol on expressions of apoE in mice livers and brains at different concentrations, and further to elucidate the effectiveness.
Methods: Sixty mice were randomly divided into the control group and 10%, 30%, 50% alcohol exposed groups (Fifteen mice in each group). Blood samples were collected at the ninth week, then livers and brains were separated from mice. Expressions of apoE were detected by immunohistochemistry, and lipids were determined by biochemistry techniques.
Results: Compared with control group, the levers of apoE were significantly lower in the alcohol exposed groups except for the 10% group (P < 0.05), and but no significant in brains (P > 0.05). TC, TG and LDL-C levels were significantly higher in the alcohol groups except for the 10% group than in the control group (P < 0.05), and HDL-C were significantly lower in the alcohol exposed groups (P < 0.05).
Conclusion: Long-term higher concentration alcohol intake decrease the expressions of apoE in livers and has an effect on lipids.