Abstract
We present the chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma and bronchogenic adenocarcinoma with bronchioloalveolar features. Using fluorescence in situ hybridization, we identified deletion of the immunoglobulin heavy chain gene in the lymphomatous component, but not the carcinomatous component. The presence of differing genetic compositions suggests a biclonal environment composed of 2 distinct neoplastic processes.
MeSH terms
-
Adenocarcinoma / genetics*
-
Adenocarcinoma / pathology
-
Aged, 80 and over
-
Breast Neoplasms / pathology
-
Breast Neoplasms / surgery
-
Carcinoma, Bronchogenic / genetics*
-
Carcinoma, Bronchogenic / pathology
-
Carcinoma, Ductal, Breast / pathology
-
Carcinoma, Ductal, Breast / surgery
-
Caspases / genetics
-
Chromosome Aberrations*
-
Chromosomes, Human, Pair 14 / genetics*
-
Female
-
Humans
-
Immunoglobulin Heavy Chains / biosynthesis
-
Immunoglobulin Heavy Chains / genetics
-
Immunohistochemistry
-
In Situ Hybridization, Fluorescence
-
Lung Neoplasms / genetics*
-
Lung Neoplasms / pathology
-
Lymphoma, B-Cell, Marginal Zone / genetics*
-
Lymphoma, B-Cell, Marginal Zone / pathology
-
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
-
Neoplasm Proteins / genetics
-
Neoplasms, Multiple Primary*
-
Sequence Deletion
Substances
-
Immunoglobulin Heavy Chains
-
Neoplasm Proteins
-
Caspases
-
MALT1 protein, human
-
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein