Anti-CD3 antibody-induced lymphocyte proliferation: a new tool for the prenatal diagnosis of some inherited immune deficiencies

Biol Neonate. 1991;59(4):253-6. doi: 10.1159/000243351.

Abstract

We have compared anti-CD3 monoclonal antibody-induced proliferation of T lymphocytes from normal human fetuses and neonates with that of adult T cells. In contrast to data in the literature, we consistently observed a strong proliferative response during antenatal and perinatal life. A lack of anti-CD3-induced proliferation, despite normal responses to the mitogen phytohemaglutinin, may prove to be a useful criterion in the diagnosis of some ill-defined inherited immune deficiencies.

MeSH terms

  • Adult
  • Antibodies, Monoclonal*
  • Antigens, CD / immunology*
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • CD3 Complex
  • Female
  • Fetus / immunology
  • Humans
  • Immunologic Deficiency Syndromes / diagnosis*
  • Immunologic Deficiency Syndromes / genetics
  • Infant, Newborn
  • Lymphocyte Activation* / immunology*
  • Pregnancy
  • Prenatal Diagnosis* / methods
  • Receptors, Antigen, T-Cell / immunology*
  • Risk

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD3 Complex
  • Receptors, Antigen, T-Cell