Abstract
SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
MeSH terms
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Animals
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Brain / drug effects
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Brain / microbiology
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Cryptococcosis / drug therapy*
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Cryptococcosis / microbiology
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Cryptococcus neoformans / drug effects
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Disease Models, Animal
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Female
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Mice
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Mice, Inbred BALB C
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Polyenes / pharmacology*
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Polyenes / therapeutic use
Substances
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Antifungal Agents
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Polyenes
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SPA S 843