Subject-specific non-linear biomechanical model of needle insertion into brain

Comput Methods Biomech Biomed Engin. 2008 Apr;11(2):135-46. doi: 10.1080/10255840802296665.

Abstract

The previous models for predicting the forces acting on a needle during insertion into very soft organs (such as, e.g. brain) relied on oversimplifying assumptions of linear elasticity and specific experimentally derived functions for determining needle-tissue interactions. In this contribution, we propose a more general approach in which the needle forces are determined directly from the equations of continuum mechanics using fully non-linear finite element procedures that account for large deformations (geometric non-linearity) and non-linear stress-strain relationship (material non-linearity) of soft tissues. We applied these procedures to model needle insertion into a swine brain using the constitutive properties determined from the experiments on tissue samples obtained from the same brain (i.e. the subject-specific constitutive properties were used). We focused on the insertion phase preceding puncture of the brain meninges and obtained a very accurate prediction of the needle force. This demonstrates the utility of non-linear finite element procedures in patient-specific modelling of needle insertion into soft organs such as, e.g. brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomechanical Phenomena / methods*
  • Brain / physiology*
  • Computer Simulation
  • Elasticity
  • Hardness
  • Humans
  • Models, Biological*
  • Needles*
  • Prosthesis Implantation / methods*
  • Punctures / instrumentation*
  • Punctures / methods*
  • Stress, Mechanical
  • Viscosity