Abstract
A new triterpenoid with a rearranged ursane skeleton, 3beta-acetoxyl-11alpha-methoxybauer-8-en-7alpha-ol ( 1), two new ursane triterpenoids, 1alpha,5alpha-dioxy-11alpha-hydroxyurs-12-en-3-one ( 2) and urs-3beta,13alpha,18beta-triol ( 3), together with three known ursane triterpenoids ( 4- 6) were isolated from the rhizome of Vladimiria muliensis. Their structures were elucidated on the basis of spectroscopic methods (IR, EIMS, HRESIMS, 1D and 2D NMR, and X-ray crystallography diffraction). Compounds 2 and 4 exhibited modest antimicrobial activity against Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, and Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology*
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Asteraceae / chemistry*
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Bacillus cereus / drug effects
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Candida albicans / drug effects
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Drugs, Chinese Herbal
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Enterococcus faecalis / drug effects
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Plants, Medicinal / chemistry*
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Pseudomonas aeruginosa / drug effects
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Rhizome / chemistry
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Staphylococcus aureus / drug effects
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Anti-Infective Agents
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Drugs, Chinese Herbal
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Triterpenes