Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation

Clin Exp Hypertens. 2008 Feb;30(2):133-41. doi: 10.1080/10641960801931923.

Abstract

The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / pharmacology*
  • Amylases / metabolism
  • Animals
  • Atenolol / pharmacology*
  • Female
  • Hypertension / metabolism*
  • Hypertension / pathology
  • Lactation*
  • Male
  • Organ Size / drug effects
  • Osmolar Concentration
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / metabolism*
  • Pregnancy Complications, Cardiovascular / pathology
  • Rats
  • Rats, Inbred SHR*
  • Rats, Wistar
  • Saliva / metabolism
  • Salivary Glands / metabolism*
  • Salivary Glands / pathology
  • Salivary Proteins and Peptides / metabolism

Substances

  • Adrenergic beta-Antagonists
  • Salivary Proteins and Peptides
  • Atenolol
  • Amylases