Abstract
The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / pharmacology*
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Amylases / metabolism
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Animals
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Atenolol / pharmacology*
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Female
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Hypertension / metabolism*
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Hypertension / pathology
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Lactation*
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Male
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Organ Size / drug effects
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Osmolar Concentration
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Pregnancy
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Pregnancy Complications, Cardiovascular / metabolism*
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Pregnancy Complications, Cardiovascular / pathology
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Rats
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Rats, Inbred SHR*
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Rats, Wistar
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Saliva / metabolism
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Salivary Glands / metabolism*
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Salivary Glands / pathology
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Salivary Proteins and Peptides / metabolism
Substances
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Adrenergic beta-Antagonists
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Salivary Proteins and Peptides
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Atenolol
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Amylases