Abstract
Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Carbolines / chemical synthesis*
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Carbolines / chemistry
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Carbolines / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Diarrhea Viruses, Bovine Viral / drug effects*
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Humans
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Isomerism
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Methylation
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Carbolines
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gamma-carboline