Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach

Eur J Neurol. 2008 Apr;15(4):431-3. doi: 10.1111/j.1468-1331.2008.02092.x. Epub 2008 Feb 16.

Abstract

For the first time, the multilocus approach by the set-association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8, IL-1alpha and IL-10] involved in the brain neuroinflammatory pathway in Parkinson's disease (PD), in a well-defined group of 197 PD patients and 173 control subjects from Spain. Set-association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain / metabolism
  • Female
  • Genotype
  • Humans
  • Inflammation / complications
  • Inflammation / genetics*
  • Inflammation / metabolism
  • Interleukin-10 / genetics
  • Interleukin-1alpha / genetics
  • Interleukin-6 / genetics
  • Interleukin-8 / genetics
  • Male
  • Middle Aged
  • Parkinson Disease / etiology*
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Parkinson Disease / pathology
  • Polymorphism, Single Nucleotide / genetics*
  • Spain / epidemiology
  • Tumor Necrosis Factor-alpha / genetics

Substances

  • Interleukin-1alpha
  • Interleukin-6
  • Interleukin-8
  • Tumor Necrosis Factor-alpha
  • Interleukin-10