Abstract
We previously reported the Suzuki-Miyaura reaction of N,N-dialkylaminomethyltrifluoroborates with aryl bromides. Herein, we report a further investigation of the scope and limitations of this palladium-catalyzed aminomethylation reaction. Aryl chlorides, iodides, and triflates coupled in good to excellent yields to give N,N-dialkylbenzylic amines. The aminomethylation of alkenyl bromides was also examined.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemical synthesis
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Amines / chemistry*
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Benzene Derivatives / chemical synthesis
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Benzene Derivatives / chemistry*
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Borates / chemistry*
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Catalysis
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Chlorobenzenes
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Hydrocarbons, Halogenated / chemistry
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Methylation
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Palladium
Substances
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Amines
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Benzene Derivatives
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Borates
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Chlorobenzenes
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Hydrocarbons, Halogenated
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Palladium