Abstract
Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.
MeSH terms
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Adenosine Diphosphate / metabolism
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Adenosine Monophosphate / analogs & derivatives*
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Adenosine Monophosphate / chemical synthesis
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Adenosine Monophosphate / pharmacology*
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Adenosine Triphosphate / metabolism
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Chromatography, High Pressure Liquid
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Humans
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Magnetic Resonance Spectroscopy
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Membrane Proteins / antagonists & inhibitors*
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Molecular Structure
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Platelet Aggregation / drug effects*
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Purinergic P2 Receptor Antagonists*
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Receptors, Purinergic P2Y12
Substances
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Membrane Proteins
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P2RY12 protein, human
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Purinergic P2 Receptor Antagonists
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Receptors, Purinergic P2Y12
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Adenosine Monophosphate
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Adenosine Diphosphate
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Adenosine Triphosphate