Effects interferon-2alpha on seizures in corasol-induced kindling

V I Kresyun; E V Kobolev; I V Smirnov; V V Godovan; L S Godlevskii

doi:10.1007/s10517-007-0240-6

Effects interferon-2alpha on seizures in corasol-induced kindling

Bull Exp Biol Med. 2007 Jul;144(1):8-11. doi: 10.1007/s10517-007-0240-6.

[Article in English, Russian]

Authors

V I Kresyun¹, E V Kobolev, I V Smirnov, V V Godovan, L S Godlevskii

Affiliation

¹ Odessa State Medical University, Ukraine.

PMID: 18256739
DOI: 10.1007/s10517-007-0240-6

Abstract

Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.

MeSH terms

Animals
Electroencephalography / drug effects
Interferon-alpha / therapeutic use*
Kindling, Neurologic / drug effects*
Male
Pentylenetetrazole
Rats
Rats, Wistar
Seizures / chemically induced
Seizures / drug therapy*

Substances

Interferon-alpha
Pentylenetetrazole