Abstract
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Crystallization
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DNA / chemistry*
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Hydrogen Bonding
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Models, Molecular
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Nucleic Acid Conformation
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Zinc / chemistry