A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients

Y-J Lin; L Wan; J J-C Sheu; C-M Huang; C-W Lin; Y-C Lan; C-H Lai; C-H Hung; Y Tsai; C-H Tsai; T-H Lin; C-P Chen; F-J Tsai

doi:10.1177/0961203307086031

A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients

Lupus. 2008 Feb;17(2):124-7. doi: 10.1177/0961203307086031.

Authors

Y-J Lin¹, L Wan, J J-C Sheu, C-M Huang, C-W Lin, Y-C Lan, C-H Lai, C-H Hung, Y Tsai, C-H Tsai, T-H Lin, C-P Chen, F-J Tsai

Affiliation

¹ Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

PMID: 18250135
DOI: 10.1177/0961203307086031

Abstract

Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Case-Control Studies
Gene Frequency
Genetic Predisposition to Disease / genetics
Genotype
Humans
Interleukin-18 / genetics*
Lupus Erythematosus, Systemic / ethnology
Lupus Erythematosus, Systemic / genetics*
Polymorphism, Single Nucleotide / genetics*
Severity of Illness Index
Taiwan

Substances

Interleukin-18