Copper-catalyzed synthesis of enantioenriched tetraarylethanes

Org Lett. 2008 Mar 6;10(5):741-4. doi: 10.1021/ol7027543. Epub 2008 Feb 2.

Abstract

Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2-diarylethanes via an unusual Cu(I)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Ethane / analogs & derivatives*
  • Ethane / chemical synthesis*
  • Ethane / chemistry
  • Hydrocarbons, Brominated / chemical synthesis*
  • Hydrocarbons, Brominated / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Hydrocarbons, Brominated
  • Copper
  • Ethane