Facultative endocrine progenitor cells in the adult pancreas

Cell. 2008 Jan 25;132(2):183-4. doi: 10.1016/j.cell.2008.01.004.

Abstract

Using a unique injury model of the pancreas in mouse, Xu et al. (2008) now reveal the involvement of neurogenin3, a marker for embryonic-type endocrine progenitor cells, in the formation of new insulin-producing beta cells. These neurogenin3-positive facultative endocrine progenitor cells in the adult pancreas may be of potential value for treating diabetes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Biomarkers
  • Cell Differentiation
  • Cell Proliferation
  • Gene Expression
  • Glucose / metabolism
  • Green Fluorescent Proteins / metabolism
  • Immunohistochemistry
  • Insulin-Secreting Cells / cytology*
  • Insulin-Secreting Cells / metabolism
  • Ligation
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Organ Culture Techniques
  • Pancreas / cytology*
  • Pancreas / injuries
  • Pancreatic Ducts / surgery
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Stem Cells / cytology*
  • Time Factors
  • beta-Galactosidase / metabolism

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Biomarkers
  • Nerve Tissue Proteins
  • Neurog3 protein, mouse
  • RNA, Messenger
  • Green Fluorescent Proteins
  • beta-Galactosidase
  • Glucose