Abstract
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
MeSH terms
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Binding Sites / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Histone Demethylases
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Histones / chemistry*
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Humans
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Kinetics
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Molecular Structure
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Monoamine Oxidase / chemistry
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Monoamine Oxidase / drug effects*
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Oxidoreductases, N-Demethylating / antagonists & inhibitors*
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Oxidoreductases, N-Demethylating / chemistry
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Structure-Activity Relationship
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Tranylcypromine / analogs & derivatives
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Tranylcypromine / chemical synthesis*
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Tranylcypromine / pharmacology
Substances
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Enzyme Inhibitors
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Histones
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Tranylcypromine
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Histone Demethylases
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Monoamine Oxidase
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KDM1A protein, human
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Oxidoreductases, N-Demethylating