Atlas-based indexing of brain sections via 2-D to 3-D image registration

IEEE Trans Biomed Eng. 2008 Jan;55(1):147-56. doi: 10.1109/TBME.2007.899361.

Abstract

A 2-D to 3-D nonlinear intensity-based registration method is proposed in which the alignment of histological brain sections with a volumetric brain atlas is performed. First, sparsely cut brain sections were linearly matched with an oblique slice automatically extracted from the atlas. Second, a planar-to-curved surface alignment was employed in order to match each section with its corresponding image overlaid on a curved-surface within the atlas. For the latter, a PDE-based registration technique was developed that is driven by a local normalized-mutual-information similarity measure. We demonstrate the method and evaluate its performance with simulated and real data experiments. An atlas-guided segmentation of mouse brains' hippocampal complex, retrieved from the Mouse Brain Library (MBL) database, is demonstrated with the proposed algorithm.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Anatomy, Cross-Sectional / methods*
  • Animals
  • Brain / cytology*
  • Feasibility Studies
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Mice
  • Pattern Recognition, Automated / methods*
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*