Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets

ChemMedChem. 2008 May;3(5):732-6. doi: 10.1002/cmdc.200700310.

Authors

Hong Ye¹, Cailin Chen, Han-Cheng Zhang, Barbara Haertlein, Tom J Parry, Bruce P Damiano, Bruce E Maryanoff

Affiliation

¹ Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477-0776, USA.

PMID: 18224705
DOI: 10.1002/cmdc.200700310

No abstract available

MeSH terms

Blood Platelets / drug effects*
Calcium / metabolism
GTP-Binding Protein alpha Subunits, Gq-G11 / physiology
Humans
Nucleosides / chemical synthesis*
Nucleosides / pharmacology
Platelet Aggregation / drug effects
Purinergic P2 Receptor Antagonists*
Receptors, Purinergic P2 / metabolism
Receptors, Purinergic P2Y12
Signal Transduction
Tetrazoles / chemical synthesis*
Tetrazoles / pharmacology

Substances

Nucleosides
P2RY12 protein, human
Purinergic P2 Receptor Antagonists
Receptors, Purinergic P2
Receptors, Purinergic P2Y12
Tetrazoles
GTP-Binding Protein alpha Subunits, Gq-G11
Calcium