The patient was a 58-year-old man with a mediastinal lymph node recurrence 26 months after surgical resection of squamous cell carcinoma of esophagus. We started a treatment with systemic chemotherapy (FAP chemotherapy) on the supposition of systemic recurrence. Next, chemoradiotherapy with docetaxel (DOC) was chosen for the expectation of powerful local control. Then bi-weekly DOC chemotherapy was chosen for the third-line therapy at an outpatient clinic. A complete response (CR) was observed after the sixth course and the treatment was finished at the twelfth course. CT showed CR after the treatment for six months. The prognosis of the cases with post-operative recurrences was poor, and its formation of recurrence varied. The strategy of the treatment should be considered a case-by-case.