A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line

Tissue Antigens. 2008 Mar;71(3):257-8. doi: 10.1111/j.1399-0039.2007.01001.x. Epub 2008 Jan 8.

Abstract

The new human leucocyte antigen-DRB1*0465 allele was identified in the Hodgkin's lymphoma cell line KM-H2. This novel allele differs from the DRB1*0406 allele by a single nucleotide exchange at position 288 (211) (A-->T), which results in an arginine to tryptophan amino acid replacement at codon 90 in the new allele.

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Base Sequence
  • Cell Line, Tumor
  • DNA Primers / genetics
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Histocompatibility Testing
  • Hodgkin Disease / genetics*
  • Hodgkin Disease / immunology*
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Single Nucleotide
  • Terminology as Topic

Substances

  • DNA Primers
  • HLA-DR Antigens
  • HLA-DRB1 Chains

Associated data

  • GENBANK/AM765992