5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

Kazutoshi Watanabe; Yasuhiro Morinaka; Yoshio Hayashi; Masaki Shinoda; Hiroyoshi Nishi; Nobuko Fukushima; Toshiaki Watanabe; Akira Ishibashi; Satoshi Yuki; Masahiko Tanaka

doi:10.1016/j.bmcl.2007.12.064

5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1478-83. doi: 10.1016/j.bmcl.2007.12.064. Epub 2007 Dec 28.

Authors

Kazutoshi Watanabe¹, Yasuhiro Morinaka, Yoshio Hayashi, Masaki Shinoda, Hiroyoshi Nishi, Nobuko Fukushima, Toshiaki Watanabe, Akira Ishibashi, Satoshi Yuki, Masahiko Tanaka

Affiliation

¹ Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.

PMID: 18191397
DOI: 10.1016/j.bmcl.2007.12.064

Abstract

A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.

MeSH terms

Animals
Antioxidants / chemical synthesis
Antioxidants / chemistry*
Antioxidants / pharmacology*
Free Radical Scavengers / chemical synthesis
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology
Imidazolines / chemical synthesis
Imidazolines / chemistry*
Imidazolines / pharmacology*
Lipid Peroxidation / drug effects
Memory / drug effects*
Rats
Rats, Wistar
Structure-Activity Relationship

Substances

Antioxidants
Free Radical Scavengers
Imidazolines