Insulin-releasing activity of a series of phenylalanine derivatives

Lei Tang; Juanhong Yu; Haoshu Wu; Houxing Fan; Yushe Yang; Ruyun Ji

doi:10.1016/j.ejmech.2007.11.018

Insulin-releasing activity of a series of phenylalanine derivatives

Eur J Med Chem. 2008 Sep;43(9):1997-2003. doi: 10.1016/j.ejmech.2007.11.018. Epub 2007 Dec 5.

Authors

Lei Tang¹, Juanhong Yu, Haoshu Wu, Houxing Fan, Yushe Yang, Ruyun Ji

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

PMID: 18191001
DOI: 10.1016/j.ejmech.2007.11.018

Abstract

A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds (S)-3 and (R)-3 exhibited more potent insulin-releasing activity than that of nateglinide, compound (S)-3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cricetinae
Drug Design
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology*
Insulin / metabolism*
Mice
Phenylalanine / analogs & derivatives*
Phenylalanine / pharmacology*

Substances

Hypoglycemic Agents
Insulin
Phenylalanine