Abstract
The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry*
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Cyanoacrylates / chemical synthesis
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Cyanoacrylates / chemistry*
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Cyanoacrylates / pharmacology*
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Microwaves
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Nicotiana / virology
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Plant Diseases / virology
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Plant Leaves / virology
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Stereoisomerism
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Structure-Activity Relationship
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Tobacco Mosaic Virus / drug effects*
Substances
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Antiviral Agents
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Cyanoacrylates