Abstract
IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years before the onset of non-Hodgkin lymphoma, and hematuria continued during chemotherapy. Each disease occurred after a long interval, and the clinical courses did not run parallel. The association was thought to be incidental in our cases. Chemotherapy with adrenocorticosteroids and immunosuppressants [6-mercaptopurine (6-MP) and cyclophosphamide (CY)] for leukemia and lymphoma did not affect the clinical course of IgAN.
MeSH terms
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Adrenal Cortex Hormones / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Child
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Child, Preschool
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Dipyridamole / therapeutic use
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Female
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Glomerulonephritis, IGA / complications*
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Glomerulonephritis, IGA / drug therapy
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Glomerulonephritis, IGA / immunology
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Glomerulonephritis, IGA / pathology
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Hematuria / etiology
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Hematuria / pathology
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Humans
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Immunoglobulin A / blood
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Immunosuppressive Agents / administration & dosage
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Kidney Glomerulus / immunology
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Kidney Glomerulus / ultrastructure*
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / drug therapy
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Lymphoma, B-Cell / immunology
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Lymphoma, B-Cell / pathology
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Male
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Substances
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Adrenal Cortex Hormones
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Immunoglobulin A
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Immunosuppressive Agents
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Dipyridamole