Abstract
Serum (1-->3)-beta-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Outbred Strains
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Antifungal Agents / therapeutic use*
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Aspergillosis* / diagnosis
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Aspergillosis* / drug therapy
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Aspergillosis* / microbiology
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Aspergillosis* / mortality
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Aspergillus fumigatus* / drug effects
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Aspergillus fumigatus* / isolation & purification
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Biomarkers / blood*
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Disease Models, Animal
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Humans
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Lung / microbiology
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Lung Diseases, Fungal* / diagnosis
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Lung Diseases, Fungal* / drug therapy
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Lung Diseases, Fungal* / microbiology
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Lung Diseases, Fungal* / mortality
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Mice
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Mice, Inbred ICR
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Proteoglycans
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Treatment Outcome
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beta-Glucans / blood*
Substances
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Antifungal Agents
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Biomarkers
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Proteoglycans
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beta-Glucans
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polysaccharide-K